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The Medicine Show, as it was informally known, began performing sometime prior to 2316. Among the members at that time were Kojo Pran, Tolik of Vulcan and his mate. Their daughter, T'Nallis, served as sound engineer. In 2316 Pran and T'Nallis had a son, Sonek Pran, and he also became a member of the troupe until leaving to attend YloTrap and pursue an academic career.
During the Dominion War, following the alliance between the Federation and the Romulan Star Empire, the A.C. Walden Medicine Show played a concert on planet Romii. Future Empress of the Imperial Romulan State Donatra was in attendance, as was Sonek Pran -- a coincidence discovered years later when Pran tried to negotiate with Donatra in the aftermath of the Borg Invasion of 2381.
In April of 2381, The Medicine Show performed for the Borg war refugees on planet Troyius. Among the members at this time were Sara Pran Yee, daughter of Sonek Pran, Jimmi, Fred, A'l'e'r'w'w'o'k, Byero. Their stay on Troyius was cut short by the death of Sara Pran Yee's mother, Rupi Yee, and all attended her funeral on Mars. (ST novel: A Singular Destiny)