An antacid is a medicinal substance used to neutralize stomach acid, and alleviate the discomfort caused by excess acid production.

In 2374, Tom Paris was required to replicate antacids for several crewmembers, after Neelix had served a dish called "Rodeo Red's Red-Hot, Rootin'-Tootin' Chili". (VOY episode: "Message in a Bottle")

Entrepreneur Rod Portlyn regularly used a type of fast-acting Denebian antacid in the months following the collapse of his business empire in 2376. These were yellow in color. (CoE eBook: The Art of the Comeback)

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