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The Antilochus (NCC-2223) was a Federation starfleet Mercury-class warpshuttle assigned to Helaspont Station in the late 2310s.

In the year 2319, Captain Amina Sasine used the Antilochus to courier orders from Admiral Los Tirasol Mentir to Admiral John Harriman, then aboard the USS Enterprise-B. (ST - The Lost Era novel: One Constant Star)