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Antwerp was a city in the nation of Belgium on Earth, situated on the Scheldt River. Among its noted landmarks were the Boerentoren and the Cathedral of Our Lady. (Star Trek: Myriad Universes novel: A Less Perfect Union)
Antwerp was the site of an interplanetary summit in 2372 which was bombed by a Changeling infiltrator, killing twenty-seven. (DS9 episode: "Homefront") Among those investigating this bombing were Lieutenant Padraig Daniels. (TNG eBook: Slings and Arrows: The Oppressor's Wrong)
In one alternate timeline, United Earth Starfleet relocated its headquarters to Antwerp after its facilities in San Francisco were destroyed by John Frederick Paxton of Terra Prime. (Star Trek: Myriad Universes novel: A Less Perfect Union)