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Aspirin was a white crystalline derivative of salicylic acid, which was often used as an analgesic to relieve minor aches and pains or to reduce fever, or use as an anti-inflammatory medication.

When the USS Enterprise arrived at planet M-113 on a supply run in 2266, Professor Robert Crater stated that the only needs that he and his wife had was aspirin and salt tablets. (TOS novelization: The Man Trap)

In 2267, Leonard McCoy had to explain the use of aspirin to Christine Chapel. (TOS novel: Mission to Horatius)

In 2376, USS da Vinci Crewman Kenneth Caitano requested aspirin from the replicator, just before dying of brain hemorrhage caused by a sonic bullet. (SCE eBook: Malefictorum)

During an archaeological mission in 2377, Inana Skanda took aspirin for a migraine rather than the native folk remedy, yenara-root tea, preferring a remedy with a track record. (CoE eBook: Remembrance of Things Past, Book I)

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