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In 2371, a Founder posing as a Federation ambassador attempted to start a war between the Federation and the Tzenkethi by convincing the USS Defiant to set a course for Tzenketh, telling the crew that the Autarch had been overthrown. The crew were able to regain control of the Defiant before it attacked the Tzenkethi. (DS9 episode: "The Adversary")
In 2381, Korzenten Rej Tov-AA assigned Alizome, his government's top intelligence operative, to manipulate the Romulan government so as to install a Praetor unlikely to attempt to use the Typhon Pact to dominate the Coalition. (ST - Typhon Pact novel: Rough Beasts of Empire)