An autograph was a signature of a notable person.

When in 2268 and aboard the USS Enterprise, Benjamin Sisko was able to obtain James T. Kirk's autograph by providing Kirk with a Starfleet crew manifest to sign. (DS9 episode: "Trials and Tribble-ations")

Sisko chose not to tell Temporal Investigations agents Dulmur and Lucsly he had Kirk's autograph in case they confiscated it. (DS9 novelization: Trials and Tribble-ations)

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