Cabrius Prime was a planet in or near Federation space, located in the Cabrius star system, somewhere in the galaxy's Alpha or Beta Quadrants.

In the late 2330s decade, Cabrius Prime was destroyed by a supernova. Prior to its destruction, Cabrius Prime's inhabitants had been afflicted with a disease similar to one that struck Bajor in the early 2370s. (DS9 novel: Wrath of the Prophets)

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