For other uses, see Canis.

The Canis Major region was an area of the Milky Way Galaxy located between the Gum Nebula and the Orion Reach. It was the destination of the USS Titan in 2381, and the location of the planet Droplet. (TTN novel: Over a Torrent Sea)

It is unclear what the relationship is between this region and the Canis Major constellation, if any.