The Caxtonians are a humanoid species from the Alpha or Beta Quadrants. They have a reputation for being excellent pilots, although some believed they had poor social skills, fiery tempers and an unpleasant body odour.

A Caxtonian freighter captain was drinking in the Captain's Table when James T. Kirk and Hikaru Sulu visited it. Some of the patrons were irritated by his odor. (TOS novel: War Dragons)

In 2371, a Caxtonian pilot helped Benjamin Sisko and the crew to discover the legendary Jibetian ship Nibix, which had been missing for eight centuries. (DS9 novel: The Long Night)

A year later, Quark claimed that Miles O'Brien had killed two Caxtonians. Their brother later confronted O'Brien, starting a riot in Quark's. (DS9 novel: The Heart of the Warrior)