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In late 2267, Ceti Alpha VI exploded, causing serious damage to the ecology of its neighboring planet, Ceti Alpha V, after its orbit was affected. Its destruction was unwittingly caused by experiments on Mirdonyae artifacts undertaken by Doctor Carol Marcus and Lieutenant Ming Xiong of Vanguard Station (Starbase 47). (VAN novel: Storming Heaven)
The change in orbit devastated the surface of Ceti Alpha V, which was home to a colony of Eugenic Augments led by Khan Noonien Singh. The Augment colony barely survived, and Khan's wife died when infected by a Ceti eel - the only native life form left on the planet.
In 2285, the USS Reliant was assigned to check Ceti Alpha VI as a possible test site for the Genesis Device. However, due to a gravitic sensor-issue caused by the recent passage of an anomaly through the star system, the starship's scanners mistakenly failed to register the planetary debris as belonging to Ceti Alpha VI itself. This error would not finally be recognized until early in 2287. (TOS movie: Star Trek II: The Wrath of Khan, TOS novel: To Reign in Hell: The Exile of Khan Noonien Singh)