In late 2267, Ceti Alpha VI exploded causing serious damage to the ecology of the neighboring planet, Ceti Alpha V, after its orbit was affected. Its destruction was unwittingly caused by experiments on Mirdonyae Artifacts undertaken by Doctor Carol Marcus and Lieutenant Ming Xiong of Starbase 47-Vanguard. (VAN novel: Storming Heaven)
The change in orbit devastated the surface of Ceti Alpha V, which was home to a colony of augments led by Khan Noonien Singh. The augment colony barely survived, and Khan's wife died when infected by a Ceti eel - the only native life form left on the planet.