Chaffee could refer to:
- Roger B. Chaffee, a 20th century Human astronaut
- Chaffee (NX-74205/01), a Type-10 shuttlecraft destroyed in 2376
- USS Chaffee (Oberth class), an Oberh-class, Gagarin-subclass starship active in the 23rd century
- USS Chaffee (NX-74205-A), a Type-10 shuttlecraft active in the 25th century
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