Chameloids were a species of shapeshifters. Prior to 2293, they were believed by the Federation to be mythical. In that year, Captain James T. Kirk and Doctor Leonard McCoy encountered a Chameloid named Martia on the Klingon prison colony Rura Penthe. (TOS movie: Star Trek VI: The Undiscovered Country) McCoy later theorized that the Chameloids were native to Rura Penthe, given Martia's apparent adaptation to cold weather. (CoE eBook: Ghost)
Following the Dominion attack on the Antwerp Conference in 2372, a Chameloid named Wusekl was illegally detained and imprisoned on Triex, as the people believed he was a Founder. (ST novel: Articles of the Federation)
In the late 24th century, Federation archaeologists on Drura Sextus discovered Tholian crystal-lattice documentation of a race of genetically engineered shapeshifters. Two of these shapeshifter were responsible of the death of Dr. Jennifer Almieri and Counselor Han Duren on Earth in 2377. Captain Montgomery Scott theorized that these shapeshifters were Chameloids, given the proximity of Drura Sextus to Klingon space. (CoE eBook: Ghost)
- Bart Faulwell states in Ghost that Martia was the only Chameloid ever on record; however, at the time of this story, Wusekl's case was still sealed by court order on Triex.