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In the 1600s, the English playwright William Shakespeare fictionalised Cleopatra's relationships with the Romans Julius Caesar and Mark Antony in his play Antony and Cleopatra. While visiting the USS Enterprise in 2266, Lenore Karidian commented that to Captain James T. Kirk that they were "the Caesar of the stars and Cleopatra to worship him." (TOS episode: "The Conscience of the King")
Cleopatra was studied by the 23rd century historian Alexander Lazarus, who created an android, with the psi-clone, and imbued it with Alexander's personality and history. This android, like other androids of Lazarus, created a city on Gamma Alpha V. She was likely destroyed in the explosion of Gamma Alpha V on Stardate 10:26.3. (TOS comic: "The Legacy of Lazarus")