The couple would take joint assignments throughout their careers, to avoid separation. For this same reason, they elected never to have children. One of their assignments was a three-year mission to a mining colony on Reganus.
In late 2367 or early 2368, while the Prescotts were stationed on planet Cygnus IV, they decided to be divorced. However, they had a change of heart after being exposed to an unknown pathogen. Both were cured of the infection, and maintained their resolution to remain together. (TNG - Strange New Worlds II short story: "Calculated Risk")