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Defiant could refer to:
- Starships and vehicles:
- ISS Defiant (24th century), mirror universe adapted Defiant-class destroyer/escort
- USS Defiant, an NX-class starship
- ISS Defiant (23rd century)
- USS Defiant (NCC-1764), a Constitution-class cruiser/heavy cruiser
- USS Defiant (Constitution class) (II), a second Constitution-class cruiser/heavy cruiser, also NCC-1764
- USS Defiant (NX-74205) (I), the first Defiant-class destroyer/escort
- USS Defiant (NX-74205) (II), formerly the USS Sao Paulo NCC-75633, second Defiant-class destroyer/escort
- USS Defiant (alternate reality NCC-1764)
- USS Defiant (alternate reality NX-74205)
- Real-life topics
- Defiant (episode), a DS9 episode