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Detroit was visited three times by time-travelling Xindi-Reptilians in an effort to construct a bio-weapon against Humans. Their efforts were foiled by Captain Jonathan Archer and Subcommander T'Pol. (ENT episode: "Carpenter Street")
In 2251, James T. Kirk incorrectly guessed that Gary Mitchell was either from Detroit or Chicago. He was wrong on both counts, as Mitchell was born and raised in New York City. (TOS - My Brother's Keeper novel: Republic)