Like a lethal bacillus coursing through the bloodstream of the galaxy, a fiendish master plan has spread death and terror across the 24th century—until two heroic captains risk everything to stamp out the evil at its source!
For more than a decade, since the very beginning of the starship Enterprise's mission, unknown enemies have unleashed a string of deadly biological weapons throughout the Alpha Quadrant, inflicting ghastly epidemics upon the Romulans, the Cardassians, the Bajorans, and even the Federation. Now, at long last, Captain Jean-Luc Picard joins forces with Captain Mackenzie Calhoun of the starship Excalibur to track down and confront the hidden architects of the plagues—and avenge the deaths of thousands!


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BenzBethBurgoyne 172Mackenzie CalhounCamboniChoSi CwanZolon DargDataElias FrobisherGeorge GarfieldGwixJanosEdward JellicoKapelKat'leenZak KebronDavid KendrowKwintGeordi La ForgeRobin LeflerLodecMacaskillJoe MankowskiMaxwellMark McHenryMcKeanMonasteroJoe MorrisAlynna NechayevO'SheaMike PalumboPetronellaJean-Luc PicardMorgan PrimusProfessorQadrilWilliam T. RikerSelaSelarElizabeth ShelbyShunaboSilverSoletaStonnVara SyndraGerrid ThulDeanna TroiVandeliaWorfZeen
Referenced only 
Mendan AbbisAroninBorg QueenJack CrusherRichard DaystromDiksonDiSpignoFalkarGazilloHendersonJayJack McNicolBruce Carmel MuddThaddius RikerThomas RikerLwaxana TroiWattanbeHoratio WrigleyNatasha Yar

Starships and vehiclesEdit

Andorian prison shipUSS Enterprise-Eescape podUSS ExcaliburUSS GrissomUSS IndependenceRomulan warbirdrunaboutshuttle


Alpha QuadrantArcharia IIIArgelius IIDaystrom StationEarthKara'sNarobi IISan FranciscosickbayTen-ForwardThul SphereWrigley's Pleasure Planet
Referenced only 
Bajoran wormholeCardassiaDanterDaystrom InstituteDeep Space 4Delta QuadrantDemilitarized ZoneEstarcion IVMarsRisaRomulusStarbase 18Terok NorTopekaXenex

Races and culturesEdit

Referenced only 

States and organizationsEdit

StarfleetThallonian EmpireUnited Federation of Planets

Other referencesEdit

asteroid fieldbaseball batbeanbagBendii syndromebicentennialblack holeblasterbombbulletcatchronometercloaking devicecommunicatorcomm unitcryo-mistdaggerdisruptorDominion WarDouble HelixDyson Spherefinger cymbalGreat Bird of the GalaxygrozitGuardian of Foreverholodeckhologeneratorhologramholo unithypersonic showerimzadiisolinear chipkatraklaxonknifelatinummicrochipmicroscopenaniteOmega 9pasteboardphaserphoton torpedopipplasma torpedoplaying cardpon farrPrime Directivepsychic backlashreplicatorResolution of Non-InterferencescalpelscannersensorshampooshawlStone AgesupernovaswordtennistigerTolasian night slicertranspondertransportertricorderturboliftVenus drugVulcan nerve pinchwarp corewhipZynterian camouflage field



  • The Double Helix series was a Next Generation storyline that featured each installment crossing over with another franchise series. "Double or Nothing" in particular crossed TNG with Star Trek: New Frontier.


published order
Previous novel:
TNG numbered novels Next novel:
The First Virtue
Previous novel:
Double Time
NF Stories Next novel:
The Quiet Place
Previous novel:
Double Helix
Next novel:
The First Virtue
chronological order
Previous Adventure:
What You Leave Behind
Chapters 11-15
Pocket Next Adventure:
The Left Hand of Destiny, Book One
Previous Adventure:
The Human Factor
Voyages of the
USS Enterprise (NCC-1701-E)
Next Adventure:
I, Q
The above chronology placements are based on the primary placement in 2376.
The Pocket Books Timeline places events from this story in one other timeframe:
Previous Adventure:
Seven Years Earlier
Next Adventure:
Star Trek: New Frontier publications and stories
Novels House of CardsInto the VoidThe Two-Front WarEnd GameMartyrFire on HighOnce BurnedDouble or NothingThe Quiet PlaceDark AlliesExcalibur (RequiemRenaissanceRestoration)Cold WarsBeing HumanGods AboveStone and AnvilAfter the FallMissing in ActionTreasonBlind Man's Bluff
Short stories and novellas "Death After Life" • No Limits ("Loose Ends" • "All That Glisters..." • "Waiting for G'Doh, or, How I Learned to Stop Moving and Hate People" • "Lefler's Logs" • "Alice, on the Edge of Night" • "Revelations" • "Turning Point" • "'Q'uandary" • "Oil and Water" • "Singularity" • "The Road to Edos" • "A Lady of Xenex" • "Making a Difference" • "Performance Appraisal" • "Redemption" • "Out of the Frying Pan" • "Through the Looking Glass" • "A Little Getaway") • "Stone Cold Truths" • "Pain Management" • "Cutting Ties" • "Homecoming"
eBooks The Returned, Part 1The Returned, Part 2The Returned, Part 3 Comics Double TimeTurnaround ("Part I" • "Part II" • "Part III" • "Part IV" • "Part V")
Omnibuses New FrontierPrometheansTurnaround German omnibuses KartenhausZweifrontenkrieg

External linkEdit