Drema Station was a Federation starbase constructed in the Drema system, beyond an asteroid belt believed to have been the remains of the system's fifth planet. The station was constructed in 2369, to support the Federation mission to Drema IV, a Federation protectorate.

Admiral Jameson Tucker was commander of Drema Station when it initially came on line in late 2369, and the station's chief medical officer was Doctor Katherine Pulaski. In 2377, the CMO was Doctor Mary Klesaris.

Upon her graduation from Starfleet Medical Academy in 2377, Doctor Sarjenka requested a posting to Drema Station. (SCE eBook: Progress)