The ECS Silk Road was a cargo ship owned by the Earth Cargo Service in the 22nd century.

In 2157, the ECS Silk Road made contact with the pre-warp natives of the fourth planet in the Psi Serpentis star system who they referred to as Saurians. In 2162, Starfleet sent Federation Commissioner Soval aboard the USS Essex to follow up on making official first contact with the Saurians. (ENT - Rise of the Federation novel: A Choice of Futures)

The ship was named for the Silk Road, an ancient network of trade routes that ran throughout Asia, from China to the Mediterranean Sea.

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