Zeiss served as the commanding officer of the USS San Francisco during the Kessok incident of the year 2378. After the Cardassian forces of Legate Matan launched a surprise attack on Arturus III, The San Francisco was among the ships sent to defend it. Later, Zeiss took the San Francisco to aid the USS Sovereign in destroying Kessok solarformers. Zeiss was present during formal first contact with the Kessok. (ST video game: Bridge Commander)
- The role of Captain Zeiss was played by voice actor Carolyn Hennesy.