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The weapon was first encountered by Federation forces when the Breen entered the Dominion War as allies of the Dominion in 2375, at the Second Battle of Chin'toka. Since the Federation Alliance had never encountered the weapon before, it was especially effective against them. The weapon works by draining the energy of targeted ships, disabling their engines, weapons, and shields, thus making them easy targets for conventional weapons. Amongst the vessels lost to the weapon was the USS Defiant. (DS9 episode: "The Changing Face of Evil"; WizKids module: Attack Wing)
The Klingon ship IKC Ki'tang was not affected as its tritium intermix chamber had been modified. Several weeks later, Kira Nerys and the Cardassian Liberation Front hijacked a Jem'Hadar attack ship for Starfleet to analyze its energy dissipators. (DS9 episodes: "When It Rains...", "Tacking Into the Wind")