During the war, she recruited Doctor Selar of the USS Enterprise-D to serve as both a medic, and to provide a logical, objective viewpoint of the conflict. To end the war, Q agreed to conceive a child with Q. Q gave birth shortly after the conception, with Selar serving as midwife. (VOY episode: "The Q and the Grey"; NF short story: "'Q'uandary")
She later appeared on the USS Enterprise-E in 2374, when Betazoid scientist Lem Faal's experiments at the Galactic barrier threatened to release the entity known as 0 from his confinement. (TNG - The Q Continuum novels: Q-Space, Q-Zone, Q-Strike)
In 2380, Lady Q appeared to Admiral Kathryn Janeway to warn her away from personally investigating a seemingly dead massive Borg cube. Janeway ignored her warning and Lady Q stood witness as Janeway was assimilated and transformed into the new Borg Queen.
With the destruction of the cube and the apparent death of Janeway, Lady Q took Janeway away from the scene to face some unknown "destiny". She served as a direct participant in the events of the mission by serving aboard the USS Enterprise-E, in the guise of Jon Stephens (TNG novel: Before Dishonor)