The Ferengi-Lytasian conflict was a four year clash between the Ferengi Alliance and the Lytasians. It took place between the Ferengi years 18101 and 18105. It was the only interstellar war ever fought by the Ferengi. (DS9 reference: Legends of the Ferengi)

The Battle of Prexnak, which would become the most famous battle in Ferengi history, was fought during the conflict. Ten Ferengi fought against two hundred and seventy-three Lytasians and were killed. (DS9 episode: "The Magnificent Ferengi")

Many souvenirs were created both during and after the war, including novelty headskirts, special Marauder Mo action figures and accessories, music recordings and posters. Many of these items became highly sought collectibles whose value multiplied in the years to follow. (DS9 reference: Legends of the Ferengi)

During the Lytasian conflict, Squeeb was performing his military service. He was injured and had to have a metal plate inserted into his head. (DS9 novel: Legends of the Ferengi)