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Florence (or Firenze in Italian) is a city on Earth, located in the nation state of Italy. The city was the capital of the Tuscany region of Italy, located on the banks of the Arno River in north-central Italy. The city is regarded as the birthplace of the Renaissance on Earth.
The human painter and scientist Leonardo da Vinci lived in Florence for a number of years. Centuries later, a holographic recreation of Da Vinci expressed a desire to Kathryn Janeway to leave the city. (VOY episode: "Concerning Flight")