Frontier could refer to:
- The Frontier, a class M moon
- Core frontier, a region of space near the core of the Milky Way Galaxy
- Empty Frontier, a region of space bordering the Romulan Star Empire
- CDS Frontier, a Cardassian starship
- Frontier Accord, an agreement between the Federation and the Gorn Hegemony
- Frontier-class (starship), a Starfleet starship type
- Frontier-class (space station), a space station type
- USS Frontier, a Starfleet starship
- Orion Frontier Mercantile Association, an Orion trade group
- Klingon 4th Frontier Force, a Klingon military unit
- Klingon 3rd Frontier Naval Division, a Klingon military unit
- Star Trek: New Frontier, a novel series
- New Frontier (omnibus), a collection of the first four books
- "Dark Frontier", a Voyager episode
- Star Trek V: The Final Frontier, the fifth Star Trek movie
- The Final Frontier (game), a video game based on the film
- First Frontier, a TOS novel
- Final Frontier, a TOS novel
- Leonard McCoy, Frontier Doctor, a comic series
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