The Galen border conflicts were a series of skirmishes between the Talarian Republic and the United Federation of Planets in the late 2350's.

One skirmish occurred on the planet Castal I, where the Talarian Endar had lost his son to the Federation. Another occurred on the planet Galen IV, where Jono lost both his parents and was taken in by Endar. (TNG Suddenly Human)

The conflict ended with a treaty between the two powers.