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Galileo could refer to:
- Starships and vehicles:
- USS Galileo (NCC-16600), Mission-class courier
- USS Galileo (Nebula-class)
- Galileo (NCC-1701/7) (I), the Galileo from 2264-2267
- Galileo (NCC-1701/7) (II), the Galileo from 2267-2268
- Galileo II
- Galileo (NCC-1701/3), also known as Galileo III
- Galileo (NCC-1701-A/05), the Galileo in 2287 with the Enterprise-A
- Galileo (NCC-1701-B/7), the Galileo in 2319 with the Enterprise-B
- Galileo (NCC-1701-D/07), the Galileo in 2364 with the Enterprise-D
- Galileo (mirror)
- Galileo (alternate reality)