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In 2268, the USS Intrepid was surveying the Gamma 7A system, during which time, the system and ship were destroyed by a giant space amoeba, and the systems' billions of inhabitants were killed. This amoeba was later stopped by the crew of the USS Enterprise. (TOS episode: "The Immunity Syndrome")
In 2259 of the alternate reality created by the Narada's temporal incursion, the USS Enterprise participated in a mission to the system. Said mission earned Nyota Uhura a Special Commendation. (Star Trek App)