A glob fly was an animal found on Qo'noS. It was an insect half the size of a Terran mosquito, which did not sting, but made an irritating buzzing sound. (TNG episode: "The Outrageous Okona")

In 2376, Klag referred to the Kreel as being like glob flies. (TNG novel: Diplomatic Implausibility)

In an alternate 2400, Odo shapeshifted into a glob fly aboard the Boreth. It was among the smallest animals Odo felt comfortable transforming into. (DS9 novel: The War of the Prophets)