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The Grand Canal (Canal Grande in Italian) was a significant canal in the city of Venice (or Venezia in Italian) in Italy on Earth. The canel served as a major route for water-traffic through the Venice and was a popular attraction for visitors to the city.
In late 2379, while campaigning for the position of Federation President, Nanietta Bacco's office in her campaign headquarters in Venezia overlooked the Grand Canal. (TNG novel: A Time for War, A Time for Peace)