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The Great Ascension was an event that came to Earth in an alternate timeline.

In an alternate timeline where the Augments won the Eugenics Wars, the Great Ascension followed shortly. Under the guidance of the First Khan, the Human race were completely transformed through genetic engineering into the Children of Khan. This enhanced race of mankind then began a campaign of conquest across the Alpha Quadrant. (DS9 novel: Seeds of Dissent)

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