Hesperan thumping cough is an illness.

Federation passports recommend that an individual receive immunization for Hesperan thumping cough before travelling. (ST reference: Federation Passport)

Several crewmembers of the USS Stargazer contracted Hesperan thumping cough in the 2330s. (SGR novel: Three)

In 2364, Wesley Crusher commented to his mother that a virus he had contracted on Quazulu VIII was worse than Hesperan thumping cough. (TNG episode: "Angel One")

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