- ISS Prometheus seems to be the mirror universe counterpart of the USS Prometheus (NCC-59650-A) , a Prometheus-class starship, in service in the 25th century.
- On June 29th, 2012, Star Trek Online's mirror universe Prometheus-class was replaced by a mirror-Cerberus-class.
|Prometheus-class light cruiser/advanced escort starships|
| Federation, Starfleet|
| Cerberus • Hercules • Icarus • Meridian • Prometheus • Prometheus-A • Titan|
| Terran Empire Starfleet|