Ikalia was a star system near the Federation-Klingon border.

In late 2368 or early 2369, Ikalia was the site of a battle with the Romulan Star Empire, during which several Starfleet officers were kidnapped. (ST video game: Legacy)

In 2373, the Federation turned Ikalia over to the Klingon Empire, as part of the negotiations reestablishing the Khitomer Accords.

As of 2381, it was the site of an underfunded research station. Following the Borg Invasion of 2381, it was designated as a refugee destination for the low-class members of Klingon society. (ST novel: A Singular Destiny)