Ismene Zavos was a human female of unspecified profession in the mid 24th century. She died, along with her husband Xun Chen, in 2378.

She and Xun were the parents of Antigone Chen, but did not appear to have a close relationship with her, to the extent that Anitgone's daughter T'Ryssa Chen did not learn the identities of her grandparents until three years after their deaths. (TNG novel: Losing the Peace)