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Isoboramine is a neurotransmitter in Trill that connects the synaptic functions of a host to their Trill. A reduction in isoboramine levels is harmful to both and a fall below forty percent of normal necessitates the removal of the symbiont. Benzocyatizine can be used to increased isoboramine levels. (DS9 episode: "Equilibrium")
In 2285, after being injured in a shuttle accident, Torias Dax's isoboramine levels could not be increased, forcing Trill doctors to remove Dax and give it to a new host, Joran Dax. (DS9 episode: "Equilibrium")
In 2371, the memory block used by the Trill Symbiosis Commission to keep Joran's memories from resurfacing began to break down, lowering Jadzia Dax's isoboramine levels, threatening the removal of Dax and Jadzia's life. (DS9 episode: "Equilibrium")
After Ezri Dax was joined with Dax in 2375, Doctor Fulghum of the USS Destiny inhibited her isoboramine levels to keep the memories of the past hosts of Dax from surfacing too quickly. (DS9 short story: "Ninety-three Hours")
In 2376, Girani Semna discovered isoboramine in Shakaar Edon's body during his autopsy, showing he had been joined and revealing the connection to the Trill the parasites had. (DS9 novel: Lesser Evil)