Jacqueline Kennedy (July 28, 1929 – May 19, 1994) was an American female who lived during the 20th century. As the wife of U.S. President John F. Kennedy, she was the First Lady of the United States from January 20, 1961 until her husband's assassination on November 22, 1963.
On one occasion, Gary Seven and Roberta Lincoln prevented Professor Tepesch from brainwashing the Kennedys. (TOS novel: Assignment: Eternity)
In 2154, Captain Jonathan Archer and Daniels saw an image of Kennedy and her husband in the time stream as the timeline reset itself. (ENT episode: "Storm Front")