"Home is where you make it, doctor. And my family has always seemed more at home among the stars."

— Jamie Samantha Kirk

Jamie Samantha Kirk was a Starfleet ensign stationed on Deep Space Nine in 2370. Kirk was involved in a research project on an energy conducting artifact found in the Gamma Quadrant when a Romulan delegation was aboard the station. Jannek, the Romulan ambassador, was the son of the Romulan commander who faced Jamie's ancestor James T. Kirk at the first 23rd century Romulan/Federation encounter at Icarus IV. This was a point of conflict as his family still has a grudge against the Kirk family. (DS9 comic: "Blood and Honor").

As James T. Kirk's only (known) child, David Marcus, was killed on the Genesis Planet, it is likely she is descended from one of Jim's nephews, the sons of George Samuel Kirk, Jr. (possibly Craig Kirk, who has a daughter of which little is known), rather than being a direct descendant.