- "I am returning Earth to its rightful owners. I am giving Earth back to humanity, back to Human beings. It is my life's work, it's what I was born to do, and there is no one—not an alien, not a Human—that will stop me from achieving it."
- —John Frederick Paxton, 2155
Toward the end of promoting xenophobia, Paxton authorized the creation of a Human-Vulcan binary clone from the DNA of Earth Starfleet officers T'Pol and Charles Tucker III, as proof of the idea the Human race was at risk. Paxton also plotted to commandeer the Verteron Array on Mars, and threatened to destroy Starfleet Command—site of the negotiations for the Coalition of Planets—if all aliens did not leave the Sol system immediately. He was eventually stopped by Captain Jonathan Archer and the crew of the Enterprise, and taken into custody. (ENT episodes: "Demons", "Terra Prime")
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In an alternate timeline, Paxton successfully destroyed Starfleet Command, leading to a rise of isolationism on Earth lasting into the mid-23rd century. After his imprisonment, he stopped taking Rigelian gene therapy to cure his Taggart's Syndrome and consequently died a martyr. This contributed to the Isolationist Party's achievement of a majority of seats in the Parliament of United Earth in 2161. (TOS - Myriad Universes novel: A Less Perfect Union)