Judith Sisko was the daughter of Joseph Sisko and sister of Benjamin Sisko. She was a musician who performed in an orchestra.

In 2374 Judith visited Earth as part of a tour of the Sol system with her orchestra. (DS9 novel: Hollow Men)

In 2376 Judith along with her father and the O'Brien family travelled to Bajor to join Kasidy Yates for the birth of her daughter, Judith's niece. (DS9 novel: Unity)