Judith Sisko was the daughter of Joseph Sisko and Rebecca Sisko and the sister of Benjamin Sisko, Aaron Sisko and Samuel Sisko. Judith was a musician who performed in the Martian Philharmonic.
Around 2350, Benjamin Sisko helped his sister construct a robotic skeleton float for Mardi Gras in New Orleans. The float later crashed against a balcony railing on Bourbon Street and Sisko blamed Judith for the malfunction, although she believed he knew it was his fault for overloading the servos. (DS9 - Mission Gamma novel: Lesser Evil)
Judith was briefly romantically involved with Tomas Roeder, who once took her to a performance of Coppélia in New York City. (DS9 novel: Hollow Men)
Sisko lived in Portland in the early 2370s. (DS9 episodes: "Past Tense, Part I", "Homefront")
In 2374, Judith visited Earth as part of a tour of the Sol system with her orchestra. (DS9 novel: Hollow Men)
In September 2376, Judith, along with her father and the O'Brien family, travelled to Bajor to join Kasidy Yates for the birth of her daughter, Judith's niece. (DS9 novel: Unity)
In 2381, Judith gave a eulogy at the funeral of her father. (ST - Typhon Pact novel: Rough Beasts of Empire)