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The Keempo Expanse was a region of space between the territories of the Goeg Domain and the United Federation of Planets. The closest distance between the Domain and Federation borders were 100 light-years. The Nystrom system lay on the Domain side of the Keempo Expanse. (TOS novel: The Shocks of Adversity)
In 2267, the USS Enterprise was the first Federation Starfleet starship to traverse the Keempo Expanse and make contact with the Domain during a deep space assignment. (TOS novel: The Shocks of Adversity)