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Three months into the Dominion War, Starfleet Intelligence located a facility deep in Cardassian space. Benjamin Sisko and his crew were assigned to destroy it, travelling to the installation in a Jem'Hadar fighter and by beaming down a canister filled with ultritium. Although not everything went to plan, the facility was successfully destroyed. (DS9 episode: "A Time to Stand", DS9 novelization: Call to Arms...)
During the war, several fleets attacked ketracel-white facilities, not always being successful. The Achilles-class was later used to make such assaults, although the Dominion countered this by using Jem'Hadar super carriers, which had ketracel-white facilities of their own. (DS9 video game: Dominion Wars)