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When Bashir was five years old, Kukalaka became his first "patient" when he performed surgery to stitch close a hole in the bear's leg. From then on Bashir cared for and repaired Kukalaka to the best of his abilities. (DS9 episode: "The Quickening")
In 2372 Bashir allowed Leeta, who he was dating at the time, to borrow Kukalaka. When Bashir and Leeta split up, Bashir recruited Jake Sisko and Nog to get Kukalaka back, in exchange for five liters of anaerobic metabolites suspended in a hydrosaline solution. (DS9 episode: "In the Cards")