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The Lantaru sector was a sector of space, located somewhere in the Alpha or Beta Quadrants, in or near Federation territory. In the 23rd century, Lantaru was the location of a mining colony, Tanaris IX, and a scientific outpost, Outpost 771. This sector was also the location of a covert space station used by Doctor Bendes Kettaract in his efforts to create a stable Omega molecule. After Kettaract's molecule destablized, the resulting energy release destroyed the fabric of subspace through much of the sector. (TOS - Section 31 novel: Cloak)
By the 24th century, the Lantaru sector was notorious for being impassible by anything faster than impulse speed. The true nature of this damage was suppressed by the Federation and it was claimed this was a natural phenomenon. (VOY episode: "The Omega Directive")