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In the 21st century, the population of Levinius V experienced an outbreak of mass insanity. In the year 2267, the crew of the Federation starship USS Enterprise concluded that this was caused by blastoneurons, a type of neural parasite. (TOS episode & Star Trek 2 novelization: Operation -- Annihilate!; TOS - Operation: Annihilate comic: "Part 1")
In 2371, a science team from Levinius V left their homeworld to visit Starbase Deep Space 9 in preparation for a tour of the Gamma Quadrant led by Jadzia Dax. (DS9 - The Maquis: Soldier of Peace comic: "Vacation's Over")