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While Federation replicators were able to create levithi nuts, they were unable to recreate the complex organic molecules which made up the essential oil in the nuts. This caused a problem for many Efrosians who left Efros Delta, such as Doctor Xin Ra-Havreii, because they had to have real nuts exported from Efros.
When Dr. Ra-Havreii supply of levithi nuts had run out in late 2379 and he began to suffer from sickness, the USS Titan's chief medical officer, Dr. Shenti Yisec Eres Ree was able to secure a supply from Chief Moreno from the USS Seyetik, who claimed to have four containers of levithi nuts in the ship's cargo bay. (TTN novel: Taking Wing)