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Lewis could refer to:
- Lewis (Enterprise), a crewmember aboard the USS Enterprise.
- Lewis (nurse), a nurse aboard the USS Enterprise-D.
- Lewis (engineer), an engineer aboard the USS Enterprise-D.
- Lewis (Starbase 27), a Starfleet officer on Starbase 27 in the 23rd century.
- Lewis (Commander), a Starfleet officer in the 24th century.
- Fenton Lewis
- Louis Blanchard
- Luis, an engineer aboard the Xhosa.
- Starships and vehicles:
- Real-life topics: