- Septos
- Sepux
- Sequoia (disambiguation)
- Sequoia class
- Sera
- Serafin's Survivors
- Seran
- Serassh
- Serbia
- Sered
- Serel (Malcorian)
- Seren
- Seren (Cardassian)
- Seren (Vulcan)
- Serena
- Serena Gibson
- Serenity Square
- Serenti
- Seres Province
- Seret
- Serex class
- Serf
- Sergane
- Sergeant
- Sergei Davidovich
- Sergei Dominico
- Sergei G. Gorshkov
- Sergei Prokofiev
- Sergey Rozhenko
- Sergey Varazdinski
- Sergio Mendoza
- Sergoz
- Serialist poets
- Series 15,000 Artificial Intelligence Module
- Series Alpha sensor probe
- Seril
- Serlay
- Serling
- Sern'apa
- Sern Leshon
- Sernar
- Sero
- Serona
- Seros
- Seros system
- Serosian
- Serotonin
- Serova
- Serpens
- Serpent's Ridge
- Serpent worm
- Serpentine
- Serpents Among the Ruins
- Serpents in the Garden
- Serra'nob
- Serrataal
- Serrias
- Serris
- Serron (Kelvin timeline)
- Serrosel ch'Nayla
- Serum
- Servado
- Servado's Agony
- Servant
- Service patch
- Service robot
- Servin
- Servitor race
- Servitrix
- Servius Tullis
- Servo
- Servo-miner
- Servo (disambiguation)
- Sesha Lindalan
- Seshto
- Sesilor
- Seska
- Seska (mirror)
- Sespar's Revenge
- Sessai Choro
- Sessen
- Sessethantis zh'Cheen
- Sessica
- Sessilent
- Sessl
- Sestarci 124
- Sestok
- Sestra Weapons
- Sestro
- Set'leth
- Seta
- Setal (disambiguation)
- Setal system
- Setek
- Setek (Vulcan)
- Setekh Project
- Seth Ascher
- Seth Cable
- Seth Goddard
- Seth Goldberg
- Seth Lerner
- Seth Maslan
- Seth Matthews
- Sethan
- Sethan (Hemanite)
- Sethan (Vulcan)
- Sethe
- Sethe (animal)
- Sethe (disambiguation)
- Setheleyis th'Rasdeth
- Sethen class
- Sethik's disease
- Setkar Base
- Setlik
- Setlik II
- Setlik III
- Setlik III Massacre
- Setlik IV
- Setrin Yeta
- Setro
- Settie Lar
- Settlement Council
- Settlesand to-Vensre
- Settoon
- Seudath
- Seudath (mirror)
- Seung Kee Reese
- Sevaijen class
- Sevala
- Sevek
- Sevek (mirror)
- Seven's Reckoning
- Seven-up
- Seven Deadly Sins
- Seven Lubak
- Seven and Seven
- Seven of Nine
- Seven of Nine's sphere
- Seven of Nine (1ST)
- Seven of Nine (novel)
- Seven of Seven
- Seven v Seven
- Seventeen Seconds
- Seventeenth planets
- Seventh
- Seventh Dynasty
- Seventh Guarantee
- Seventh Heaven
- Seventh House of Betazed
- Seventh planets
- Severalty Front
- Severin Alonzo Hart
- Severn-Anyar
- Severus VI
- Sevet
- Sevor
- Sevoris
- Sevrin (disambiguation)
- Sevrin class
- Sevrok
- Sewage
- Seyann
- Seyar Mandas-Pok
- Seyer
- Seylok
- Seyom
- Seyrel
- Sezanian
- Sezedi
- Sgheel
- Sh'Dastisar
- Sh'Neroth
- Sh'Raan
- Sh'Raan class
- Sh'Raazn
- Sh'Rreev
- Sh'Zenne
- Sh'aow
- Sh'dama Age
- Sh'nab
- Sh'rr
- Sh'tan
- Sh'tok
- Sh'uk
- Sh'vhal
- Sh'vhal class
- Sha'Kurian
- Sha'Kurian Ducal Territories
- Sha'Kurian House of Lords
- Sha'amil
- Sha Afshar
- Sha Afshar (23rd century)
- Sha Afshar (24th century)
- Sha Ka Ree
- Shaa
- Shaal
- Shaal's battlecruiser
- Shaal's commander
- Shaandra
- Shabren
- Shabren's Fifth Prophecy
- Shabren's Prophecies
- Shabren class
- Shackleton
- Shackleton Expanse
- Shackleton Expanse Campaign Guide
- Shad
- Shad (Argelian)
- Shad Ona
- Shaddan
- Shades of Gray
- Shadi
- Shadir
- Shadis
- Shadow
- Shadow's Advance
- ShadowVeil class
- Shadow (novel)
- Shadow (organization)
- Shadow 1
- Shadow Group
- Shadow Lord
- Shadow Market
- Shadow Play
- Shadow Proclamation
- Shadow Treasurers
- Shadow class
- Shadow of Heaven
- Shadow of the Machine
- Shadowed Allies
- Shadowheart
- Shadowheart (Demon)
- Shadowplay (episode)
- Shadows, in the Dark
- Shadows Have Offended
- Shadows and Symbols
- Shadows in the Garden
- Shadows in the Garden (poem)
- Shadows of P'Jem
- Shadows of the Indignant
- Shadows of the Past
- Shadows on the Sun
- Shadra
- Shadrasi
- Shafer
- Shaffer
- Shah of Iran
- Shahar
- Shahkur
- Shahna
- Shahr
- Shahr System Patrol
- Shaitani
- Shajara
- Shakaar
- Shakaar Edon
- Shakaar resistance cell
- Shakar Navanti
- Shakarri Province
- Shakedown
- Shakedown (STO)
- Shakedown (comic)
- Shakedown (short story)
- Shakedown cruise
- Shakedown log
- Shakikein
- Shakiristi River
- Shal'tiar
- Shal Tul
- Shala
- Shalaft's Syndrome
- Shalaven
- Shali bahn
- Shalkara
- Shallash
- Shallash (disambiguation)
- Shalom
- Shalra
- Shalvan
- Shana Winslow
- Shanador
- ShanaiKahr
- Shanak
- Shandaken
- Shandor
- Shandrak
- Shandrak I
- Shandrak II
- Shandrak II-A
- Shandrak II-B
- Shandrak II-C
- Shandrak II-D
- Shandrak III
- Shane Samson
- Shane Zeranski
- Shangdi
- Shangdi system
- Shange
- Shange shunt
- Shanghai
- Shanghai Expresscraft
- Shanghaied
- Shanghaied (comic)
- Shanghaied (short story)
- Shangri-La
- Shangri-La (disambiguation)
- Shangri-La class
- Shani
- Shaniq
- Shannar
- Shannara Rozhenko
- Shannon
- Shannon (Enterprise)
- Shannon (USS Aldebaran)
- Shannon (transport)
- Shannon Cochran
- Shannon Moulton
- Shannon O'Donnel
- Shannon Sekaya Janeway
- Shanok
- Shanradeskel ch'Larn
- Shansar
- Shantherin th'Clane
- Shantil
- Shao
- Shape of the Union
- Shaper
- Shaper (Sarkadesh)
- Shapeshifter
- Shapiro
- Shapley (disambiguation)
- Shapley Center
- Shar's family
- Shar (disambiguation)
- Shar D'An
- Shar Rapha
- Shara Albright
- Shara Eman
- Shara Ruos
- Sharaba
- Sharak
- Sharan Singh
- Sharanna
- Sharash'di
- Shard class