- USS Sovereign (NCC-74977-A)
- USS Sovereign (prototype)
- USS Sovereign personnel
- USS Soyuz
- USS Spaker
- USS Spann
- USS Sparon
- USS Sparrow
- USS Sparrow (23rd century)
- USS Sparrow (24th century)
- USS Sparrowhawk
- USS Sparrowhawk (24th century)
- USS Sparrowhawk (NX-605)
- USS Sparta (2360s)
- USS Sparta (2381)
- USS Sparta (scout)
- USS Spector
- USS Spectre
- USS Speedwell
- USS Sphinx (Centaurus class)
- USS Sphinx (NCC-93469)
- USS Spica (Excelsior class)
- USS Spica (NCC-1815)
- USS Spirit
- USS Spirit (Akira class)
- USS Spirit (NX-79995)
- USS Spitfire
- USS Springfield (NCC-1963)
- USS Springfield (prototype)
- USS Spruance
- USS Spruance (Saber class)
- USS St. Helen
- USS St. Lawrence
- USS St. Louis
- USS St. Mihiel
- USS Stafford
- USS Stafford (Baker class)
- USS Stafford (Nebula class)
- USS Stalingrad
- USS Stalingrad (Akira class)
- USS Stalingrad (NCC-4461)
- USS Stalwart (23rd century)
- USS Stalwart (NCC-75635)
- USS Stalwart (NCC-78010)
- USS Stanley (mining freighter)
- USS Star Empire
- USS Star Empire (Ulysses class)
- USS Star League
- USS Star System
- USS Star Union
- USS Starbound
- USS Starfinder
- USS Stargazer-A (Intrepid class)
- USS Stargazer-A (prototype)
- USS Stargazer (NCC-2893)
- USS Stargazer (NCC-2893) personnel roster
- USS Stargazer (NCC-82893)
- USS Stargazer (NCC-82893) personnel roster
- USS Stargazer (alternate timeline)
- USS Starhawk
- USS Starlight
- USS Starling
- USS Starstalker
- USS Stavanger
- USS Steamrunner
- USS Steele
- USS Stephen Decatur (Daedalus class)
- USS Stephen Decatur (NCC-6015)
- USS Sternbach (Curry class)
- USS Sternbach (NCC-97942)
- USS Steuben
- USS Stewart
- USS Stingray (NCC-4011)
- USS Stingray (Oberth class)
- USS Stockholm
- USS Stockholm (London class)
- USS Stockholm (NCC-18544)
- USS Stockholm (NCC-2789)
- USS Stockholm (NCC-60018)
- USS Stockholm personnel
- USS Stoker
- USS Stone Mountain
- USS Stonwin
- USS Storta
- USS Strasbourg
- USS Stratford
- USS Strider
- USS Striker
- USS Stromming
- USS Strong
- USS Strongbow
- USS Strother
- USS Struve
- USS Stuart
- USS Sturgeon
- USS Styx
- USS Subra
- USS Suffren
- USS Sugihara
- USS Sulaco
- USS Sulam
- USS Suleiman
- USS Suleiman (24th century)
- USS Suleiman (NCC-508)
- USS Sullivan
- USS Sultan
- USS Sumatra
- USS Summit
- USS Summons
- USS Sumter
- USS Sun Tsu (Steamrunner class)
- USS Sun Tzu (NCC-1581)
- USS Sun Tzu (NCC-2530)
- USS Sun Tzu (NCC-4347)
- USS Sun Yat Sen
- USS Sunbird
- USS Sundrass
- USS Sundweller
- USS Sungari
- USS Suomussalmi
- USS Surak (Constitution class)
- USS Surak (Oberth class)
- USS Surak personnel
- USS Suribachi (Excelsior class)
- USS Suribachi (Saladin class)
- USS Surishian
- USS Surmass
- USS Surprise
- USS Susquehanna
- USS Sussex
- USS Suswa
- USS Sutherland (2330s)
- USS Sutherland (Aegian class)
- USS Sutherland (NCC-72015)
- USS Sutherland (NCC-91800)
- USS Sutter
- USS Suvarov
- USS Sverdlov
- USS Swiderek
- USS Swift (NAR-32410)
- USS Swift (NCC-3894)
- USS Swiftsure
- USS Swiftsure (23rd century)
- USS Swiftsure (Galaxy class)
- USS Sybil
- USS Sydney (London class)
- USS Sydney (NCC-2741)
- USS Sylvania
- USS Syracuse (Aerie class)
- USS Syracuse (NCC-17744)
- USS T'Jan
- USS T'Khasi
- USS T'Klyrn
- USS T'Kumbra
- USS T'Mala
- USS T'Paal
- USS T'Pau (24th century)
- USS T'Pau (Apollo class)
- USS T'Pau (NCC-29783)
- USS T'Pavis
- USS T'Plana-Hath (24th century)
- USS T'Plana-Hath (NCC-1004)
- USS T'Pol
- USS T'Pora
- USS T'Pring
- USS T'Saura
- USS T'Shen Kovil
- USS T'Vrea
- USS T'lingShar
- USS T'mirea
- USS T'pool
- USS T'rin'saz
- USS Taaj
- USS Tacitus
- USS Tafelberg
- USS Tai Kang
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- USS Takahashi
- USS Talabani
- USS Tali
- USS Tallahassee
- USS Tallinn
- USS Talon
- USS Talos
- USS Tamara
- USS Tamberlaine
- USS Tambora
- USS Tamerlane
- USS Tamorra
- USS Tana Re
- USS Tanabe
- USS Tanaka
- USS Tandarich
- USS Tangiers
- USS Tangiers (NCC-1590)
- USS Tangiers (mining freighter)
- USS Tannenberg
- USS Tannenberg (NCC-1735)
- USS Tannenberg (NCC-4303)
- USS Tao Feng
- USS Taranto
- USS Tarawa
- USS Tarshish
- USS Tarso Voon
- USS Tashmaji
- USS Tasmania
- USS Taupo
- USS Tauriel
- USS Taurus (NCC-2512)
- USS Taurus (NCC-4018)
- USS Taurus (NCC-605)
- USS Taussig
- USS Tavda
- USS Taveuni
- USS Taylor (Akula class)
- USS Taylor (Baker class)
- USS Taylor (Galaxy class)
- USS Teagarden
- USS Tecumseh
- USS Tecumseh (NCC-14934)
- USS Tecumseh (NCC-4402)
- USS Tecyr
- USS Tedder
- USS Tegethoff
- USS Tehran
- USS Teich
- USS Temeraire (NCC-1689)
- USS Temeraire (NCC-65387)
- USS Temir
- USS Tempest (NCC-1852)
- USS Tempest (NCC-97700)
- USS Tempest (Sovereign class)
- USS Templar (Akira class)
- USS Templar (NCC-96047)
- USS Temple (2330s)
- USS Temple (mining freighter)
- USS Tempus
- USS Tenacious
- USS Tenochtitlan
- USS Terebellum
- USS Tereshkova (23rd century)
- USS Tereshkova (NCC-1811)
- USS Tereshkova (NCC-97936)
- USS Terminator
- USS Tern
- USS Terror
- USS Tesla
- USS Texas Ranger
- USS Thales
- USS Thames
- USS Thant
- USS Thantasaras
- USS Thantos
- USS Thatcher (Akira class)
- USS Thatcher (NCC-855)
- USS Thebes
- USS Thefel
- USS Thejal
- USS Thelasa-vei
- USS Thelenth
- USS Thelev
- USS Thelian
- USS Thelonii
- USS Theodore
- USS Theodore Roosevelt
- USS Thermopolae
- USS Thermopylae (NCC-4351)
- USS Theseus (NCC-552)
- USS Theseus (NCV-88050)
- USS Theseus (NX-1887)
- USS Theseus (NX-1987)
- USS Theseus personnel
- USS Thetis
- USS Thims
- USS Tholus
- USS Thomas B. McGuire, Jr.
- USS Thomas Paine (NCC-65530)
- USS Thomas Paine (NCC-9000)
- USS Thor (Defiant class)
- USS Thorn
- USS Thorne
- USS Thoth
- USS Threnody
- USS Thresher
- USS Thresher (NCC-1930)
- USS Thuban
- USS Thule
- USS Thunderball
- USS Thunderbird (Akira class)
- USS Thunderbird (NCC-4005)
- USS Thunderchild
- USS Thunderchild (NCC-63549-B)
- USS Thunderer
- USS Thuphylla
- USS Thurgon
- USS Thurmost III
- USS Thy'lek Shran (NCC-62151)
- USS Thy'lek Shran (NCC-90225)
- USS Tian An Men
- USS Tiber (Runabout)
- USS Tiber (mining freighter)
- USS Tiberius (23rd century)
- USS Tiberius (NCC-4363)
- USS Tiberius (Sovereign class)
- USS Ticonderoga (Defiant class)
- USS Ticonderoga (NCC-1650)
- USS Ticonderoga (NCC-1736)
- USS Ticonderoga (NCC-2206)
- USS Ticonderoga (NCC-3111)
- USS Ticonderoga II
- USS Tien Shan
- USS Tiger
- USS Tigershark
- USS Tigress
- USS Tigris
- USS Tikhov (NCC-1067)
- USS Tikhov (NCC-1067-M)
- USS Tikopai
- USS Tikuma
- USS Tilly
- USS Timberwolf
- USS Timoshenko
- USS Timur
- USS Tinalynn
- USS Tinian
- USS Tintagel
- USS Tirpitz
- USS Tisdale
- USS Titan
- USS Titan (Defiant class)
- USS Titan (NCC-1777)
- USS Titan (NCC-2752)
- USS Titan (NCC-98100)
- USS Titan (Prometheus class)
- USS Titan personnel
- USS Titian Plain
- USS Titov
- USS Tobias
- USS Todd
- USS Tofua
- USS Tog
- USS Togo
- USS Tokugawa
- USS Tokyo (London class)
- USS Tokyo (NCC-1656)